FT3203 BIO-ORGANIC CHEMISTRY SYLLABUS | ANNA UNIVERSITY B.TECH FOOD TECHNOLOGY 3RD SEMESTER SYLLABUS REGULATION 2008 2011-2012 BELOW IS THE ANNA UNIVERSITY THIRD SEMESTER B.TECH FOOD TECHNOLOGY DEPARTMENT SYLLABUS IT IS APPLICABLE FOR ALL STUDENTS ADMITTED IN THE YEAR 2011-2012 (ANNA UNIVERSITY CHENNAI,TRICHY,MADURAI,TIRUNELVELI,COIMBATORE), 2008 REGULATION OF ANNA UNIVERSITY CHENNAI AND STUDENTS ADMITTED IN ANNA UNIVERSITY CHENNAI DURING 2009
FT3203 BIO-ORGANIC CHEMISTRY L T P C
(Common for IBT, Food and Pharmaceutical Technology) 3 0 0 3
UNIT I INTRODUCTION TO CHEMISTRY 13
Chirality, Enantiomers, Diastereomers, Enantiotopic Faces, Absolute configuration RS
normetclature, Bijvotes method of determining absolute configuration. Con-formers :
Ethane, butane, cyclohexane – Reactivity due to change in conformers Reactions : SN1,
SN2, E1, E2, Addition of electrophile on a double bond, Hy-dride transfer mechanisms
Cannizaro’s reaction. Reactivity : Kinetics of Reactions, First order and kinetics of enzyme
Determination of Δ G ‡, Δ H ‡, Δ S ‡. Thermodynamics: Boltzmans equation, Gibbs –
Helmoltz equation. Acid – Base catalysis – Structure of water.
UNIT II INTRODUCTION TO ORGANIC SYNTHESIS 10
Useful Organic Transformations Reterosynthetic Analysis.
Case Studies : Synthesis of Cholesterol, Synthesis of Chlorophyll.
UNIT III ENZYMES 5
MM kinetics – other mechanisms for enzyme action – Methods for following enzyme
reactions – Analysis of Enzymatic reactions.
UNIT IV MECHANISMS 13
Case Studies : Lipase, Carboxypeptidases, Monooxygenases – Esterases Case Study:
Engineering an Enzyme – Subtilisn.Case Study: Allostery ATpase Mechanisms of enzymes
in a Pathway : Case Study : Serratia marcasens & Prodigiosin.Domain Movements in
Enzymes MD simulations Case Study : Lipase.
UNIT V BIOLOGICAL SUPERMOLECULES 4
Supramolecular Systems – Ion Channels – photosynthesis – artificial enzymes – catalytical
antibodies – ribozymes..
TOTAL: 45 PERIODS
TEXT BOOKS
1. Page, M.I., and A. Williams, “Organic and Bioorganic Mechanisms,” Pearson India
Edition, 1997
2. Ariya, K. and T. Kumtake, “ Supramolecular Chemistry : Fundamentals and Applications
“, Springer India Edition, 2006.
3. Morrison, R.T. and T.N. Boyd “Organic Chemistry”, 6th Edition, Prentice Hall of India,
2003.
4. Palmer, Trevor “Enzymes: Biochemistry, Biotechnology, Clinical Chemistry”,
Affiliated East-West Press Pvt. Ltd., 2004.
REFERENCE
1. Fersht, Alan “Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis
and Protein Folding”, W.H. Freeman, 1998.
FT3203 BIO-ORGANIC CHEMISTRY L T P C
(Common for IBT, Food and Pharmaceutical Technology) 3 0 0 3
UNIT I INTRODUCTION TO CHEMISTRY 13
Chirality, Enantiomers, Diastereomers, Enantiotopic Faces, Absolute configuration RS
normetclature, Bijvotes method of determining absolute configuration. Con-formers :
Ethane, butane, cyclohexane – Reactivity due to change in conformers Reactions : SN1,
SN2, E1, E2, Addition of electrophile on a double bond, Hy-dride transfer mechanisms
Cannizaro’s reaction. Reactivity : Kinetics of Reactions, First order and kinetics of enzyme
Determination of Δ G ‡, Δ H ‡, Δ S ‡. Thermodynamics: Boltzmans equation, Gibbs –
Helmoltz equation. Acid – Base catalysis – Structure of water.
UNIT II INTRODUCTION TO ORGANIC SYNTHESIS 10
Useful Organic Transformations Reterosynthetic Analysis.
Case Studies : Synthesis of Cholesterol, Synthesis of Chlorophyll.
UNIT III ENZYMES 5
MM kinetics – other mechanisms for enzyme action – Methods for following enzyme
reactions – Analysis of Enzymatic reactions.
UNIT IV MECHANISMS 13
Case Studies : Lipase, Carboxypeptidases, Monooxygenases – Esterases Case Study:
Engineering an Enzyme – Subtilisn.Case Study: Allostery ATpase Mechanisms of enzymes
in a Pathway : Case Study : Serratia marcasens & Prodigiosin.Domain Movements in
Enzymes MD simulations Case Study : Lipase.
UNIT V BIOLOGICAL SUPERMOLECULES 4
Supramolecular Systems – Ion Channels – photosynthesis – artificial enzymes – catalytical
antibodies – ribozymes..
TOTAL: 45 PERIODS
TEXT BOOKS
1. Page, M.I., and A. Williams, “Organic and Bioorganic Mechanisms,” Pearson India
Edition, 1997
2. Ariya, K. and T. Kumtake, “ Supramolecular Chemistry : Fundamentals and Applications
“, Springer India Edition, 2006.
3. Morrison, R.T. and T.N. Boyd “Organic Chemistry”, 6th Edition, Prentice Hall of India,
2003.
4. Palmer, Trevor “Enzymes: Biochemistry, Biotechnology, Clinical Chemistry”,
Affiliated East-West Press Pvt. Ltd., 2004.
REFERENCE
1. Fersht, Alan “Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis
and Protein Folding”, W.H. Freeman, 1998.
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